Analytical Data
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Gene name
hamp
- Application
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Alternative Names
hamp; Hepcidin
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Species
Larimichthys crocea
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A1Z0M0
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Expression Region
65-85aa
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Molecular Weight
2.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HAMP (Hepcidin Antimicrobial Peptide) is a vital regulator of iron homeostasis and plays a crucial role in the body's response to inflammation and infection. Initially discovered for its antimicrobial properties, HAMP regulates systemic iron levels by controlling the absorption of dietary iron and the release of iron from macrophages and liver cells. Dysregulation of HAMP is implicated in various disorders, such as anemia of chronic disease, hereditary hemochromatosis, and iron overload syndromes. Understanding the structure and function of HAMP is essential for developing potential therapeutic strategies targeting these conditions. Recent research has focused on the recombinant production of HAMP to study its functional mechanisms, structure-function relationships, and interactions with iron transport proteins and receptors. This has enabled scientists to explore the peptide's role not only in iron metabolism but also in various pathophysiological processes, including inflammation and infection. The ongoing investigation into HAMP and its recombinant forms aims to enhance our understanding of iron regulation and develop innovative treatments for related disorders, thereby addressing a significant clinical challenge associated with iron management in diseases.
