Analytical Data
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Gene name
HAND2
- Application
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Alternative Names
Class A basic helix-loop-helix protein 26
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P61296
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Expression Region
1-180aa
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Molecular Weight
47.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HAND2, a member of the Hand family of basic helix-loop-helix transcription factors, plays a crucial role in various developmental processes, particularly in the embryonic development of the heart and limbs. Research has shown that HAND2 is essential for proper cardiac morphogenesis and the formation of the outflow tract, as well as limb patterning and development. Its expression is tightly regulated and is implicated in several congenital disorders, including hypoplastic left heart syndrome and certain limb malformations. The study of HAND2 recombinant proteins has become increasingly important for understanding its functional mechanisms and interactions with other regulatory proteins during development. By producing and analyzing HAND2 in its recombinant form, researchers can elucidate its structure-function relationships, investigate its regulatory pathways, and explore its potential as a therapeutic target for congenital anomalies. Furthermore, recombinant HAND2 proteins can serve in functional assays to identify binding partners and downstream effectors essential for its signaling pathways. This research not only deepens our comprehension of HAND2's biological roles but also paves the way for innovative strategies in regenerative medicine and developmental biology.
