Analytical Data
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Gene name
Hist1h2ba
- Application
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Alternative Names
Histone H2B, testis (Testis-specific histone H2B) (Th2b)
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Species
Mouse
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P70696
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Expression Region
2-127aa
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Molecular Weight
21.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Histone variant H1.2, encoded by the Hist1h2ba gene, plays a crucial role in chromatin structure and gene regulation. As a member of the linker histone family, it is involved in stabilizing higher-order chromatin organization and influencing nucleosome positioning. Research on Hist1h2ba has gained momentum due to its implications in various biological processes, including DNA repair, transcription control, and cellular differentiation. Abnormal expression or mutations in histone variants are associated with several diseases, particularly cancer, where altered chromatin dynamics contribute to tumorigenesis. Recent studies have focused on the production of recombinant Hist1h2ba proteins to facilitate in-depth biochemical and structural analyses, allowing researchers to explore its specific interactions with DNA and other chromatin-associated proteins. The ability to manipulate and characterize this histone variant in vitro has provided valuable insights into its functional mechanisms and potential as a therapeutic target. Overall, the study of Hist1h2ba offers a window into the complexities of epigenetic regulation and highlights the importance of histone variants in maintaining genomic integrity and cellular homeostasis.
