Analytical Data
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Gene name
MRPL42
- Application
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Alternative Names
28S ribosomal protein S32, mitochondrial ;MRP-S32 ;S32mt39S ribosomal protein L31, mitochondrial ;L31mt ;MRP-L31
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y6G3
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Expression Region
33-142aa
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Molecular Weight
40.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPL42, a gene encoding a mitochondrial ribosomal protein, has garnered attention in recent years due to its essential role in mitochondrial function and protein synthesis. Mitochondria are crucial organelles responsible for energy production, and any dysfunction in their components can lead to various metabolic disorders and diseases, including neurodegenerative conditions and certain types of cancer. The MRPL42 protein is part of the mitochondrial ribosome's structure, impacting the synthesis of mitochondrial proteins, which are vital for the organelle's operation. Research has shown that abnormalities in MRPL42 expression can disrupt mitochondrial activity, leading to impaired ATP production and increased oxidative stress. Understanding the function and regulation of MRPL42 is therefore critical, as it could pave the way for developing therapeutic strategies targeting mitochondrial dysfunction. Additionally, the potential use of MRPL42 as a biomarker for mitochondrial-related diseases invites further investigation. Recent efforts to express and purify recombinant MRPL42 protein will facilitate in-depth studies on its biochemical properties and interactions, ultimately contributing valuable insights into mitochondrial dynamics and pathologies associated with MRPL42 dysregulation.
