Analytical Data
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Gene name
NANOS2
- Application
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Alternative Names
NANO2_HUMAN; Nanos homolog 2; Nanos homolog 2 Drosophila; NANOS2; NOS-2; NOS2
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P60321
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Expression Region
1-138aa
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Molecular Weight
31.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NANOS2 is a member of the NANOS family of RNA-binding proteins, which play crucial roles in germ cell development and the maintenance of pluripotency in embryonic stem cells. Research into NANOS2 has gained significance due to its pivotal role in the regulation of germline-specific gene expression and its involvement in the suppression of transcription during early embryonic development. In many organisms, including mice and humans, NANOS2 is essential for the proper formation and differentiation of primordial germ cells. The protein functions by binding to specific mRNAs, facilitating their stability or degradation, and thus influencing the fate of germ cells. Recent studies have shown that perturbations in NANOS2 function can lead to reproductive issues and link it to various developmental disorders. Given its important biological functions, understanding the mechanisms of NANOS2 has implications for reproductive biology, developmental biology, and potential therapeutic applications in regenerative medicine and infertility treatment. Consequently, the characterization of NANOS2 recombinant protein has become a crucial focus for researchers aiming to elucidate its biochemical properties, interaction partners, and functional pathways within the cell. Overall, NANOS2 serves as a vital component in the regulation of germline development, and ongoing investigations into its properties will enhance our understanding of germ cell biology and inform potential clinical applications.
