Analytical Data
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基因名
Pmaip1
- Application
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别名
Protein Noxa (Noxa)
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种属
Mouse
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9JM54
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表达区间
1-103aa
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分子量
15.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Pmaip1, also known as Phorbol-12-myristate-13-acetate-induced protein 1, is a member of the Noxa family of proteins and plays a significant role in cellular responses to stress, particularly in apoptosis and tumorigenesis. Research has demonstrated that Pmaip1 is a transcriptional target of the p53 tumor suppressor, linking it to critical pathways in cancer biology. Elevated expression of Pmaip1 has been associated with enhanced apoptotic processes in response to various cellular stresses, making it a potential biomarker for cancer prognosis and a target for therapeutic interventions. Moreover, studies indicate that Pmaip1 can modulate mitochondrial function and is involved in regulating the balance between cell survival and death. The recombinant expression of Pmaip1 allows for the detailed study of its structure and function, providing insights into the molecular mechanisms underlying its role in cancer progression and cell death. As the understanding of Pmaip1's functions advances, it holds promise for developing novel cancer therapies that can exploit its pro-apoptotic properties to selectively target cancer cells while sparing normal tissues.
