Analytical Data
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基因名
Frizzled-6
- Application
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种属
Bovine
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q2KJH1
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表达区间
294-409aa
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分子量
40.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Frizzled-6 (Fzd6) is a member of the frizzled family of G protein-coupled receptors, which play crucial roles in the Wnt signaling pathway, a fundamental mechanism that regulates various biological processes, including cell proliferation, differentiation, and migration. Studies have shown that Fzd6 is involved in the regulation of neural development and may have implications in cancer biology, where aberrations in Wnt signaling often lead to tumorigenesis. Recent research has focused on the structural and functional characterization of Fzd6, aiming to elucidate its precise role in signaling networks. The reconstitution of Fzd6 as a recombinant protein allows for in-depth biochemical and biophysical studies, facilitating the understanding of ligand-receptor interactions and downstream signaling cascades. This knowledge can provide insights into potential therapeutic targets for diseases associated with Wnt signaling dysregulation. Additionally, investigating Fzd6's interactions with other signaling molecules and its effects on cellular behavior can contribute to a comprehensive understanding of its function in developmental processes and disease states. Overall, the study of Fzd6 as a recombinant protein is pivotal for advancing our knowledge of Wnt signaling and its broader implications in biology and medicine.
