Analytical Data
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Gene name
PPM1B
- Application
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Alternative Names
Protein phosphatase 2;C isoform beta ;PP2;C-beta
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75688
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Expression Region
2-192aa
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Molecular Weight
36.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPM1B, also known as protein phosphatase magnesium-dependent 1B, is a critical enzyme involved in the regulation of various cellular processes, including cell cycle progression, apoptosis, and stress response. Its primary role is to dephosphorylate target proteins, thereby reversing the actions of kinases and maintaining cellular homeostasis. Research into PPM1B has gained momentum due to its potential implications in cancer biology, where its expression levels and activity may influence tumor growth and metastasis. Abnormal regulation of PPM1B has been linked to several diseases, including various forms of cancer, highlighting its role as a potential biomarker for disease prognosis and as a therapeutic target. Additionally, PPM1B is implicated in the regulation of critical signaling pathways, including those mediated by p53, NF-κB, and other oncogenic factors. Recent studies have focused on the development of recombinant PPM1B proteins to facilitate biochemical assays, structural analyses, and high-throughput screening for small molecule inhibitors. Such studies are essential for elucidating the enzyme's structure-function relationship and its interactions with other cellular components, ultimately leading to a better understanding of its role in health and disease. The generation of PPM1B recombinant proteins has opened new avenues for drug discovery and the potential development of PPM1B-targeted therapies, making it a significant focus in molecular and cellular biology research.
