Analytical Data
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基因名
pbpE
- Application
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别名
PBP 4* Alternative name(s): PBP 4A Penicillin-binding protein E
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种属
Bacillus subtilis
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P32959
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表达区间
1-451aa
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分子量
67.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of recombinant protein pbpE is situated within the broader context of infectious disease research, particularly focusing on pathogens that exhibit antibiotic resistance. pbpE, which encodes a penicillin-binding protein in certain bacteria, plays a critical role in cell wall synthesis and maintenance, making it a key target for antibiotics. The emergence of resistant strains renders traditional antibiotic treatments less effective, highlighting the urgent need for new therapeutic strategies. Researchers are investigating pbpE not only to understand its structural and functional properties but also to explore its potential as a vaccine candidate or a therapeutic target. The recombinant expression of pbpE protein facilitates detailed analysis of its interactions and role in bacterial physiology, enabling the identification of novel inhibitors that could disrupt its function. Additionally, generating antibodies against pbpE might provide insights into immune responses to bacterial infections. Overall, this research focuses on harnessing the understanding of pbpE to combat antibiotic-resistant bacteria, which poses a significant threat to public health worldwide.
