Analytical Data
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基因名
PTCH2
- Application
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y6C5
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表达区间
79-392aa
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分子量
40.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTCH2, or Patched2, is a key component of the Hedgehog signaling pathway, which plays a crucial role in regulating embryonic development and tissue homeostasis. This pathway is essential for cellular communication during development, influencing processes such as cell proliferation, differentiation, and migration. PTCH2, being a complementary receptor to PTCH1, has gained interest in recent years due to its involvement in various biological processes and potential implications in cancer and developmental disorders. Research has indicated that mutations or aberrations in PTCH2 can be linked to tumorigenesis, particularly in basal cell carcinoma and medulloblastoma. Moreover, PTCH2 has been recognized for its regulatory effects on cholesterol metabolism, further highlighting its significance in both developmental biology and disease states. The production of recombinant PTCH2 protein has become a focus of research to facilitate the understanding of its structure-function relationships and interactions within the Hedgehog signaling pathway. By studying the recombinant protein, researchers aim to elucidate its role in cellular signaling and identify potential therapeutic targets for diseases associated with Hedgehog pathway dysregulation. This research holds promise for advancing our knowledge of cancer biology and developing targeted therapies that could improve patient outcomes in Hedgehog-associated tumors.
