Analytical Data
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Gene name
AGTR2
- Application
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Alternative Names
AGTR2；Type-2 angiotensin II receptor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P50052
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Expression Region
1-363 aa
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AA Sequence
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
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Molecular Weight
42.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The angiotensin II type 2 receptor (AGTR2) is a G protein-coupled receptor that plays a crucial role in the regulation of cardiovascular and renal function. As a key component of the renin-angiotensin system, AGTR2 is involved in various physiological processes, including blood pressure regulation, inflammation, and cell proliferation. Research has indicated that AGTR2 is predominantly expressed in fetal tissues, with decreased expression in adult tissues, suggesting a significant role during development. Furthermore, studies have linked AGTR2 to potential therapeutic implications in conditions such as hypertension, heart failure, and renal diseases. The recombinant expression of AGTR2 allows for detailed investigations of its structure, function, and signaling pathways, facilitating the discovery of novel pharmacological agents targeting this receptor. Moreover, understanding AGTR2's interactions with ligands and other proteins can unveil new insights into its function and contribute to the development of selective AGTR2 modulators, which could offer innovative treatment strategies for cardiovascular and renal disorders. The ongoing research into AGTR2 recombinant proteins thus represents a promising avenue for advancing our knowledge of this receptor and its potential as a therapeutic target.
