Analytical Data
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基因名
ANKRD1
- Application
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别名
ANKRD1；C193；CARP；HA1A2；Ankyrin repeat domain-containing Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15327
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表达区间
1-319aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMMVLKVEELVTGKKNGNGEAGEFLPED FRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLEQ RSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKA ALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGA QIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAV RTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGAD LNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF
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分子量
39 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ANKRD1, also known as cardiac ankyrin repeat domain protein 1, is a critical regulator of cardiac development and function. Research on ANKRD1 has gained momentum due to its significant role in heart diseases, particularly in hypertrophic cardiomyopathy and heart failure. The protein is primarily expressed in the heart and is involved in various cellular processes, including transcriptional regulation, cellular signaling, and cytoskeletal organization. Its expression is tightly regulated during cardiac development and is downregulated in pathological conditions. Recent studies have highlighted the importance of ANKRD1 in myocardial remodeling and the response to stress, making it a potential biomarker for cardiac events. Moreover, understanding the molecular mechanisms governing ANKRD1 function may reveal novel therapeutic targets for treating heart diseases. Advances in recombinant protein technology have enabled the production of ANKRD1 in sufficient quantities for detailed functional studies. This allows researchers to investigate its interactions with other proteins and elucidate its role in cardiac physiology and pathology. By exploring the structure-function relationships of ANKRD1 through recombinant protein studies, scientists aim to provide insights that could lead to innovative strategies for cardiovascular intervention, contributing to improved diagnostic and treatment options for heart-related disorders.
