Analytical Data
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基因名
NR1I3
- Application
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别名
Constitutive activator of retinoid response ;Constitutive active responseConstitutive androstane receptor ;CAROrphan nuclear receptor MB67
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14994
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表达区间
2-351aa
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分子量
55.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NR1I3, also known as the Pregnane X receptor (PXR), is a nuclear receptor that plays a crucial role in the regulation of drug metabolism, xenobiotic clearance, and the maintenance of homeostasis within the body. It acts as a transcription factor, binding to specific DNA sequences and regulating the expression of target genes involved in the metabolism of various compounds, including pharmaceuticals and environmental toxins. Given its pivotal function in the detoxification process, NR1I3 has garnered significant research interest in pharmacology, toxicology, and cancer, particularly in understanding how it influences drug-drug interactions and individual variations in drug response. The study of NR1I3 recombinant proteins is essential for elucidating its molecular mechanisms and identifying potential therapeutic targets. Recombinant NR1I3 proteins can be utilized in various assays to screen for new drugs, investigate ligand-binding affinity, and assess regulatory interactions with other signaling pathways. Furthermore, the functional characterization of NR1I3 can aid in understanding its role in diseases, including liver disorders and certain cancers. As researchers continue to explore its structural properties and biological functions, the insights gained from studying NR1I3 recombinant proteins may lead to the development of novel therapeutic strategies aimed at enhancing drug efficacy and minimizing adverse effects. This underscores the importance of NR1I3 in both fundamental research and clinical applications, making it a vital focus in the fields of molecular biology and pharmacotherapy.
