Analytical Data
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Gene name
SLC39A11
- Application
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Alternative Names
(Solute carrier family 39 member 11)(Zrt- and Irt-like protein 11)(ZIP-11)
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Species
Human
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Source
E. coli
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Tag
N- His-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N1S5
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Expression Region
93-193aa
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Molecular Weight
42.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC39A11, also known as ZIP11, is a member of the Zrt/Irt-like protein (ZIP) family, which plays a crucial role in metal ion transport across cellular membranes. This protein is implicated in the uptake of zinc, an essential micronutrient involved in various biological processes, including enzyme function, antioxidant defense, and cellular signaling. Dysregulation of SLC39A11 has been associated with several pathophysiological conditions, including neurodegenerative diseases and cancer, highlighting its potential as a therapeutic target. Recent studies have focused on the structural and functional characterization of SLC39A11, particularly through the production of recombinant protein. By expressing and purifying SLC39A11 in heterologous systems, researchers aim to elucidate the mechanisms by which this transporter mediates zinc transport and to identify its regulatory elements. Understanding the biophysical properties of the recombinant protein can provide insights into its interaction with zinc and other metal ions, as well as its role in cellular homeostasis. Furthermore, this research could pave the way for developing novel interventions to modulate the activity of SLC39A11 in diseases associated with dysregulated zinc metabolism. Overall, the study of SLC39A11 recombinant protein represents an important step toward unraveling the complexities of zinc transport and its implications in human health.
