Analytical Data
-
Gene name
APOBEC4
- Application
-
Alternative Names
APOBEC4；C1orf169；Putative C->U-editing enzyme APOBEC-4
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q8WW27
-
Expression Region
1-367aa
-
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMEPIYEE YLANHGTIVK PYYWLSFSLD CSNCPYHIRT GEEARVSLTE FCQIFGFPYG TTFPQTKHLT FYELKTSSGS LVQKGHASSC TGNYIHPESM LFEMNGYLDS AIYNNDSIRH IILYSNNSPC NEANHCCISK MYNFLITYPG ITLSIYFSQL YHTEMDFPAS AWNREALRSL ASLWPRVVLS PISGGIWHSV LHSFISGVSG SHVFQPILTG RALADRHNAY EINAITGVKP YFTDVLLQTK RNPNTKAQEA LESYPLNNAF PGQFFQMPSG QLQPNLPPDL RAPVVFVLVP LRDLPPMHMG QNPNKPRNIV RHLNMPQMSF QETKDLGRLP TGRSVEIVEI TEQFASSKEA DEKKKKKGKK
-
Molecular Weight
44 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
APOBEC4, a member of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family of proteins, has garnered increasing attention in recent years due to its potential roles in nucleic acid metabolism and innate immune responses. Unlike its better-studied relatives, such as APOBEC3, which are known for their antiviral activities, APOBEC4's functions remain less understood. Research suggests that APOBEC4 may play a critical role in the editing of RNA and DNA, with implications for both cellular processes and disease mechanisms. Its expression patterns indicate a selective presence in specific tissues, hinting at functional specialization. Mutations or dysregulation of APOBEC4 could be linked to various pathological states, including cancers and autoimmune disorders. Therefore, characterizing this protein’s structure, interactions, and biochemical properties is essential for elucidating its biological roles. Recent studies have started to explore these aspects, revealing intriguing insights into its enzymatic activity and potential targets within the cell. Understanding APOBEC4 could pave the way for novel therapeutic strategies aimed at modulating its activity in disease contexts. As research on APOBEC family proteins expands, APOBEC4 stands out as a promising candidate for further investigation in both basic and applied biomedical research.
