Analytical Data
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Gene name
ASCL1
- Application
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Alternative Names
ASCL1；ASH1；BHLHA46；HASH1；Achaete-scute homolog 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P50553
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Expression Region
1-236aa
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AA Sequence
MESSAKMESGGAGQQPQPQPQQPFLPPAACFFATAAAAAAAAAAAAAQSAQQQQQQQQQQQQAPQLRPAADGQPSGGGHKSAPKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF
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Molecular Weight
29.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ASCL1, also known as achaete-scute complex homolog 1, is a critical transcription factor that plays a pivotal role in neuronal differentiation and the development of the nervous system. Its involvement in neurogenesis has garnered significant research interest, particularly in the context of neural stem cell biology and neurodevelopmental disorders. Recent studies have highlighted ASCL1's ability to promote the transition from progenitor cells to mature neurons, making it a valuable target for regenerative medicine and therapies aimed at neurodegenerative diseases. Additionally, ASCL1 has been implicated in tumorigenesis, particularly in neuroblastoma and other malignancies, where its expression correlates with aggressive phenotypes. Understanding the structure and function of ASCL1, especially through the study of its recombinant protein, is essential for elucidating its mechanisms of action and therapeutic potential. By producing ASCL1 as a recombinant protein, researchers can investigate its biochemical properties, interaction with other regulatory proteins, and role in cellular pathways. This research not only advances our understanding of neurodevelopment and cancer biology but also opens avenues for developing ASCL1-based strategies for enhancing neuronal regeneration and combating neurodegenerative diseases.
