Analytical Data
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基因名
ARPP19
- Application
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别名
ARPP19;cAMP-regulated phosphoProtein 19
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P56211
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表达区间
1-112aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMSAEVPE AASAEEQKEM EDKVTSPEKA EEAKLKARYP HLGQKPGGSD FLRKRLQKGQ KYFDSGDYNM AKAKMKNKQL PTAAPDKTEV TGDHIPTPQD LPQRKPSLVA SKLAG
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分子量
15 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARPP19 (cAMP-regulated phosphoprotein 19) is a protein that plays a crucial role in the regulation of neuronal signaling pathways, particularly those mediated by cyclic AMP (cAMP) and protein kinase A (PKA). Its significance lies in its involvement in various neurobiology processes, including synaptic plasticity and learning and memory functions. Research on ARPP19 has gained momentum due to its implication in neuropsychiatric disorders, such as schizophrenia and depression, where dysregulation of cAMP signaling is often observed. The study of recombinant ARPP19 protein allows for a detailed understanding of its structure, function, and interactions with other signaling molecules, which is essential for elucidating its role in cellular processes. Recombinant technology facilitates the production of ARPP19 in a controlled manner, enabling researchers to investigate its biochemical properties, phosphorylation states, and conformational changes in response to cAMP levels. Such studies are vital for identifying potential therapeutic targets and drug development strategies aimed at restoring normal signaling pathways in affected populations. Additionally, exploring the role of ARPP19 in various cellular contexts may provide insights into the broader mechanisms of neurosignaling and its impact on behavior and cognition. Overall, the investigation of ARPP19 as a recombinant protein stands at the intersection of molecular biology, pharmacology, and neuroscience, offering promising avenues for advancing our understanding of both fundamental biology and clinical implications in mental health.












