Analytical Data
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基因名
ASNA1
- Application
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别名
ASNA1；ARSA；ASNA1；TRC40；ATPase GET3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43681
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表达区间
1-348aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMAAGVAGWGVEAEEFEDAPDVEPLEPT LSNIIEQRSLKWIFVGGKGGVGKTTCSCSLAVQLSKGRESVLIISTDPAH NISDAFDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFEEDNMLSM GKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLL NFPTIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLP VIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKIDTHNIIV NQLVFPDPEKPCKMCEARHKIQAKYLDQMEDLYEDFHIVKLPLLPHEVRG ADKVNTFSALLLEPYKPPSAQ
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分子量
41 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ASNA1, also known as the "YihA protein" in Escherichia coli, is a highly conserved protein involved in the intracellular transport of proteins and organelle biogenesis. It plays a critical role in the targeting and translocation of proteins into the endoplasmic reticulum (ER), which is essential for proper protein folding and subsequent functionality. The significance of ASNA1 has garnered attention due to its involvement in various physiological processes, including cellular stress response and metabolism. Research into ASNA1 has revealed its potential implications in neurodegenerative diseases and cancer, where protein misfolding and ER stress are prominent features. Additionally, ASNA1's function in the mitochondrial import pathways highlights its broader relevance in cellular homeostasis. As researchers continue to explore the molecular mechanisms of ASNA1-mediated protein sorting and its interactions with other cellular components, the need for recombinant ASNA1 proteins becomes essential. This allows for detailed structural and functional studies, ultimately contributing to our understanding of ASNA1's role in health and disease, as well as its potential as a therapeutic target in conditions associated with protein misfolding and ER stress.
