Analytical Data
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基因名
BRD1
- Application
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别名
BRD1；BRL；BRPF2；Bromodomain-containing Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95696
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表达区间
556-688aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSEQVAMEL RLTPLTVLLR SVLDQLQDKD PARIFAQPVS LKEVPDYLDH IKHPMDFATM RKRLEAQGYK NLHEFEEDFD LIIDNCMKYN ARDTVFYRAA VRLRDQGGVV LRQARREVDS IGLEEASGMH LPERPA
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分子量
18 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BRD1 (Bromodomain-containing protein 1) is a member of the bromodomain and extraterminal (BET) family of proteins, which play a crucial role in the regulation of gene expression, chromatin remodeling, and cell cycle progression. Research into BRD1 has gained momentum due to its involvement in several biological processes, including transcriptional regulation and potential links to various diseases, such as cancer and neurodegenerative disorders. The protein's unique structure, characterized by its bromodomain, enables it to interact with acetylated lysines on histones, thereby facilitating the recruitment of transcriptional machinery to specific genomic locations. Given its role in modulating gene expression, BRD1 is considered a potential therapeutic target in diseases where these pathways are dysregulated. Recent studies have focused on the characterization of BRD1's interactions and its functional implications in cellular contexts, aiming to elucidate its specific contributions to disease mechanisms. Additionally, the development of small molecules that can selectively inhibit BRD1 has emerged as a promising avenue for therapeutic intervention. Understanding the precise mechanisms of BRD1's action and its effects on the epigenetic landscape could pave the way for innovative treatments that leverage its role in transcriptional regulation. As such, BRD1 remains a significant focus in the field of epigenetics and molecular biology, with ongoing research aimed at unraveling its complex functions and therapeutic potential.
