Analytical Data
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Gene name
DCX
- Application
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Alternative Names
DCX；DBCN；LISX；Neuronal migration Protein doublecortin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43602
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Expression Region
1-441aa
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AA Sequence
MKTLPLHSHCTEMQRLLPKLEMLTLGSSFCSLQGEFCQAMDSFTTVSHVGMCEETDASFNVFSPKFQFDRSHCQSLRFHQNMELDFGHFDERDKTSRNMRGSRMNGLPSPTHSAHCSFYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQSLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKASPTPQKTSAKSPGPMRRSKSPADSANGTSSSQLSTPKSKQSPISTPTSPGSLRKHKDLYLPLSLDDSDSLGDSM
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Molecular Weight
65.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DCX (Doublecortin) is a critical protein implicated in neuronal migration and the formation of the cerebral cortex during brain development. Mutations in the DCX gene are associated with various neurodevelopmental disorders, including lissencephaly, which is characterized by abnormal brain surface due to improper neuronal positioning. Research on DCX has gained momentum due to its essential role in the development of the central nervous system, particularly in the context of understanding how neuronal cells migrate and differentiate in the embryonic brain. The protein acts as a microtubule-binding factor that stabilizes microtubules, ensuring proper cell movement and organization. Given its significance in neurogenesis, DCX has attracted attention not only for its fundamental biological function but also for its potential implications in regenerative medicine and therapeutic strategies aimed at neurodevelopmental disorders. Ongoing studies focus on elucidating the molecular mechanisms through which DCX influences neuronal behavior, as well as identifying potential downstream targets that could be manipulated for therapeutic purposes. Understanding the structure and function of DCX at a molecular level may provide insights into its interactions with other cellular components, facilitating the development of novel interventions for conditions arising from its dysregulation. Overall, the exploration of DCX's role in neuronal development underscores its importance in both basic neuroscience and clinical research.
