Analytical Data
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Gene name
CD80
- Application
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Alternative Names
CD80；CD28LG；CD28LG1；LAB7；T-lymphocyte activation antigen CD80
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P33681
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Expression Region
35-242aa
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AA Sequence
VIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIW PEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEV TLSVKADFPTPSISDFEIPT SNIRRIICSTSGGFPEPHLSWLENGEEL NAINTTVSQDPETELYAVSSKLDFNMTTNHSF MCLIKYGHLRVNQTFN WNTTKQEHFPDN
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Molecular Weight
50 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CD80, also known as B7-1, is a co-stimulatory molecule primarily expressed on the surface of antigen-presenting cells (APCs). It plays a critical role in the activation of T cells by binding to its receptor CD28 on T cells, facilitating immune responses. Understanding the role of CD80 is essential in various immunological contexts, including vaccine development, cancer immunotherapy, and autoimmune diseases. Recombinant CD80 proteins have been generated to study their functional properties, interactions with various ligands, and potential applications in therapies. The use of CD80 in recombinant forms allows researchers to explore its structural characteristics, enhance T cell activation in vitro, and implement it in experimental models. This can lead to innovative approaches in modulating immune responses, paving the way for novel treatments in immunotherapy and other therapeutic interventions. Thus, the study of CD80 recombinant proteins not only sheds light on fundamental immune processes but also provides a foundation for therapeutic advancements in managing diseases driven by immune dysregulation.
