Analytical Data
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基因名
CDK3
- Application
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别名
CDK3;CDKN3;Cyclin-dependent kinase 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q00526
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表达区间
1-305aa
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氨基酸序列
MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH
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分子量
60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK3 (Cyclin-Dependent Kinase 3) is a member of the cyclin-dependent kinase family, which plays a crucial role in the regulation of the cell cycle. Unlike other CDKs, CDK3 is primarily active during the G1 phase and is involved in the phosphorylation of target proteins that control cell cycle progression and differentiation. Its activity is tightly regulated by cyclins and various other cellular mechanisms, making it a key player in maintaining proper cell cycle regulation. Recent studies have indicated that CDK3 may have implications in several pathological conditions, including cancer, where dysregulation of cell cycle progression is a hallmark. Overexpression or altered regulation of CDK3 has been linked to malignant transformation, suggesting its potential as a therapeutic target in oncogenesis. Additionally, research has highlighted CDK3's role beyond cell proliferation, including involvement in cellular responses to stress and apoptosis. Given its significant functions, understanding the structural and functional characteristics of CDK3, including its protein interactions and regulatory mechanisms, is vital for elucidating its role in health and disease. Recombinant CDK3 proteins are being studied to explore their activity in various cellular contexts, helping to identify novel inhibitors or regulators that could serve as potential therapeutic agents in cancer treatment and other disorders associated with cell cycle dysregulation. This research aims to deepen our understanding of CDK3's functions and its potential as a drug target in oncology and regenerative medicine.












