Analytical Data
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基因名
Nrg
- Application
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种属
Drosophila melanogaster
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表达系统
Baculovirus
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标签
C- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20241
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表达区间
610-814aa
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分子量
28.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Nrg (Neuregulin) is a family of growth factors that play vital roles in various biological processes, including neural development, cardiac function, and the regulation of cell signaling pathways. The study of Nrg and its recombinant (recombinant Nrg proteins) counterparts has gained significant attention due to their potential therapeutic applications in treating neurodegenerative diseases, cardiovascular disorders, and certain types of cancer. Research has revealed that Nrg binds to ErbB receptors, triggering downstream signaling cascades that influence cell survival, differentiation, and proliferation. Disruptions in Nrg signaling have been implicated in conditions such as schizophrenia and heart failure, highlighting the importance of understanding its mechanisms. The development of recombinant Nrg proteins allows for the exploration of their biological functions and therapeutic potential in controlled environments. Moreover, these studies aim to elucidate the structure-function relationships of Nrg, which can aid in the design of targeted treatments. Overall, the investigation of Nrg and its recombinant variants stands at the forefront of biomedical research, offering promising avenues for innovative therapies in a range of diseases.
