Analytical Data
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Gene name
GPR15
- Application
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Alternative Names
(Brother of Bonzo)(BoB)
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49685
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Expression Region
1-360aa
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Molecular Weight
43.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GPR15, also known as G protein-coupled receptor 15, is a member of the GPCR family, which plays a critical role in various physiological processes by mediating cellular responses to extracellular signals. This receptor has garnered significant interest due to its involvement in immune responses, particularly its expression on certain immune cells such as T cells and its role in HIV infection. Research has indicated that GPR15 serves as a co-receptor for HIV, facilitating the virus’s entry into host cells, especially in the context of mucosal transmission. Furthermore, GPR15 has been implicated in the regulation of immune cell trafficking, influencing the distribution and function of lymphocytes within tissues. Understanding the structure and function of GPR15 through the study of recombinant proteins is essential for elucidating its role in both normal physiological functions and pathological conditions, including its dual role in immune modulation and viral pathogenesis. This knowledge could pave the way for novel therapeutic strategies targeting GPR15 to modulate immune responses or inhibit HIV infection, highlighting the importance of ongoing research in this area. The development of recombinant GPR15 proteins could facilitate high-throughput screening for potential therapeutic agents and contribute to the broader understanding of GPCR biology in health and disease.
