Analytical Data
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Gene name
GDF1
- Application
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Alternative Names
GDF1；Embryonic growth/differentiation factor 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P27539
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Expression Region
254-372aa
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AA Sequence
DAEPVLG GGPGGACRAR RLYVSFREVG WHRWVIAPRG FLANYCQGQC ALPVALSGSG GPPALNHAVL RALMHAAAPG AADLPCCVPA RLSPISVLFF DNSDNVVLRQ YEDMVVDECG CR
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GDF1 (Growth Differentiation Factor 1) is a member of the TGF-β superfamily, which plays a crucial role in various biological processes including embryonic development, organogenesis, and cellular differentiation. The significance of GDF1 in developmental biology has garnered attention due to its specific expression patterns during early embryogenesis and its implication in cardiac and neural development. Research indicates that GDF1 operates through the Smad signaling pathway, influencing gene expression patterns that are vital for proper organ formation. Moreover, studies have linked GDF1 to various pathologies, including congenital heart defects, emphasizing its potential as a therapeutic target. Recent advances have facilitated the production of recombinant GDF1 protein, allowing researchers to explore its functional properties and interactions in greater detail. This recombinant protein aids in elucidating the molecular mechanisms underlying GDF1's biological activities and its potential roles in disease. Understanding the structure-function relationship of GDF1 and its signaling pathways could unveil novel strategies for regenerative medicine and targeted therapies in developmental disorders and cardiovascular diseases, making it a significant focus in biomedical research.
