Analytical Data
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Gene name
H2BC12
- Application
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Alternative Names
(H2B K)(HIRA-interacting protein 1)
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Species
Human
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60814
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Expression Region
2-126aa
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Molecular Weight
21.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
H2BC12, a member of the histone H2B family, has garnered attention in recent years due to its potential roles in chromatin remodeling and gene regulation. Histones are critical components of the nuclear architecture in eukaryotic cells, influencing DNA accessibility and, consequently, gene expression. The study of H2BC12 specifically has emerged from a growing understanding of how variations in histone proteins can affect cellular processes such as differentiation, proliferation, and response to stress. Recent research indicates that H2BC12 may be involved in the regulation of specific gene sets that are crucial for cell cycle progression and apoptosis. Additionally, aberrations in histone modifications, including those involving H2BC12, have been linked to various diseases, particularly cancers. The recombinant production of H2BC12 allows for detailed biochemical analyses, facilitating the exploration of its structure-function relationships and interactions with other chromatin-associated proteins. Understanding H2BC12's role in histone modification patterns could provide insights into the epigenetic regulation of transcription and inform therapeutic strategies for diseases associated with dysregulated gene expression. As such, the investigation of H2BC12 as a model protein holds promise for unraveling the complexities of chromatin dynamics and its implications in health and disease.
