Analytical Data
-
Gene name
KIF1A
- Application
-
Alternative Names
KIF1A；ATSV；C2orf20；Kinesin-like Protein KIF1A
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q12756
-
Expression Region
全长
-
AA Sequence
full
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KIF1A, a member of the kinesin superfamily of motor proteins, plays a crucial role in intracellular transport, particularly in the anterograde movement of organelles and vesicles along microtubules. Recent studies have highlighted the significance of KIF1A in neuronal function, as mutations in the KIF1A gene have been linked to various neurodevelopmental disorders, including intellectual disability and autism spectrum disorders. Understanding the structure and function of KIF1A is essential for unraveling its biological roles and the mechanistic pathways involved in these diseases. Research into KIF1A recombinant protein aims to elucidate its motor activity, binding interactions, and regulatory mechanisms. By generating and characterizing recombinant KIF1A, scientists can probe its interactions with other cellular components, such as microtubules and cargo proteins, providing insights into its role in cellular transport mechanisms. Moreover, the development of KIF1A-based assays may facilitate the screening of potential therapeutic compounds aimed at ameliorating the functional deficits associated with KIF1A mutations. This ongoing research not only enhances our understanding of the fundamental processes governing cellular transport but also holds promise for therapeutic advancements in the treatment of KIF1A-related disorders, emphasizing the protein's emerging significance in biomedical science.
