Analytical Data
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Gene name
CCR3
- Application
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Alternative Names
CCR3；CMKBR3；C-C chemokine receptor type 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P51677
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Expression Region
1-355aa
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AA Sequence
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
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Molecular Weight
69.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CCR3, or C-C chemokine receptor type 3, is a member of the chemokine receptor family, primarily involved in the immune response and inflammation. It plays a crucial role in the migration of eosinophils, basophils, and T-helper type 2 (Th2) cells to sites of allergic inflammation and parasitic infections. The significance of CCR3 in various pathological conditions, such as asthma, allergic rhinitis, and autoimmune diseases, has prompted extensive research into its structure, function, and signaling mechanisms. Understanding the molecular interactions and pathways associated with CCR3 is essential for developing targeted therapies aimed at modulating its activity. Recombining CCR3 protein presents opportunities for studying its biological functions in vitro and in vivo, paving the way for potential therapeutic applications. By investigating CCR3’s surface interactions and ligand binding, researchers aim to identify small molecules or antibodies that can specifically inhibit its activity, offering new strategies for treating related diseases. Furthermore, CCR3 has emerged as a potential therapeutic target due to its involvement in mediating inflammatory responses, thereby contributing to the development of novel anti-inflammatory drugs. Given the rising prevalence of allergic disorders and inflammatory conditions, the study of CCR3 and its recombinant protein continues to be a significant area of biomedical research, promising insights into the modulation of immune responses and therapeutic interventions.
