Analytical Data
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基因名
SLC30A8
- Application
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别名
SLC30A8；ZNT8；Proton-coupled zinc antiporter SLC30A8
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IWU4
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表达区间
1-369aa
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氨基酸序列
MEFLERTYLV NDKAAKMYAF TLESVELQQK PVNKDQCPRE RPEELESGGM YHCHSGSKPT EKGANEYAYA KWKLCSASAI CFIFMIAEVV GGHIAGSLAV VTDAAHLLID LTSFLLSLFS LWLSSKPPSK RLTFGWHRAE ILGALLSILC IWVVTGVLVY LACERLLYPD YQIQATVMII VSSCAVAANI VLTVVLHQRC LGHNHKEVQA NASVRAAFVH ALGDLFQSIS VLISALIIYF KPEYKIADPI CTFIFSILVL ASTITILKDF SILLMEGVPK SLNYSGVKEL ILAVDGVLSV HSLHIWSLTM NQVILSAHVA TAASRDSQVV RREIAKALSK SFTMHSLTIQ MESPVDQDPD CLFCEDPCD
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分子量
44 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC30A8, also known as zinc transporter 8 (ZnT8), is a gene that encodes a protein responsible for regulating cellular zinc levels, particularly in pancreatic beta cells. Its importance has been highlighted by genetic studies linking variants of SLC30A8 with an increased risk of type 2 diabetes. The protein functions to transport zinc ions into the insulin granules, playing a crucial role in insulin crystallization and secretion. Given that zinc is critical for insulin stability and function, understanding the mechanisms of ZnT8 can provide valuable insights into the pathophysiology of diabetes. The study of SLC30A8 recombinant protein seeks to elucidate its structure, function, and interaction with other cellular components, thereby enabling the development of targeted therapeutic strategies to improve insulin secretion and glucose homeostasis. Furthermore, investigating the functional differences between various SLC30A8 variants may help identify potential molecular targets for intervention in diabetes treatment. As such, SLC30A8 presents a significant focus for research aimed at combating the global diabetes epidemic by enhancing our understanding of zinc's role in metabolic health.
