Analytical Data
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基因名
LEPREL1
- Application
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别名
LEPREL1；LEPREL1；MLAT4；Prolyl 3-hydroxylase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IVL5
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表达区间
25-708aa
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氨基酸序列
GPPDSP RRELELEPGP LQPFDLLYAS GAAAYYSGDY ERAVRDLEAA LRSHRRLREI RTRCARHCAA RHPLPPPPPG EGPGAELPLF RSLLGRARCY RSCETQRLGG PASRHRVSED VRSDFQRRVP YNYLQRAYIK LNQLEKAVEA AHTFFVANPE HMEMQQNIEN YRATAGVEAL QLVDREAKPH MESYNAGVKH YEADDFEMAI RHFEQALREY FVEDTECRTL CEGPQRFEEY EYLGYKAGLY EAIADHYMQV LVCQHECVRE LATRPGRLSP IENFLPLHYD YLQFAYYRVG EYVKALECAK AYLLCHPDDE DVLDNVDYYE SLLDDSIDPA SIEAREDLTM FVKRHKLESE LIKSAAEGLG FSYTEPNYWI RYGGRQDENR VPSGVNVEGA EVHGFSMGKK LSPKIDRDLR EGGPLLYENI TFVYNSEQLN GTQRVLLDNV LSEEQCRELH SVASGIMLVG DGYRGKTSPH TPNEKFEGAT VLKALKSGYE GRVPLKSARL FYDISEKARR IVESYFMLNS TLYFSYTHMV CRTALSGQQD RRNDLSHPIH ADNCLLDPEA NECWKEPPAY TFRDYSALLY MNDDFEGGEF IFTEMDAKTV TASIKPKCGR MISFSSGGEN PHGVKAVTKG KRCAVALWFT LDPLYRELER IQADEVIAIL DQEQQGKHEL NINPKDEL
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LEPREL1, or leucine proline-enriched protein 1, is a protein implicated in various biological processes, particularly in the context of extracellular matrix (ECM) biology and cellular response mechanisms. It has garnered attention in recent years due to its involvement in collagen maturation and the modification of ECM components, making it significant in connective tissue disorders and potential therapeutic targets for fibrosis and other related diseases. Research indicates that LEPREL1 plays a crucial role in stabilizing the structure of collagen fibers, thus influencing the physical properties of tissues. Mutations or dysregulation of LEPREL1 expression can lead to abnormal ECM formation, contributing to pathological conditions such as osteogenesis imperfecta and other skeletal abnormalities. Understanding the molecular mechanisms and biological functions of LEPREL1 is essential for elucidating its role in developmental processes and disease pathogenesis. The development of recombinant LEPREL1 proteins offers a promising approach to study the protein's interaction with various ECM components and its functional role in cellular contexts. This could pave the way for novel therapeutic strategies targeting LEPREL1-related pathways, highlighting the need for further investigation into its structural properties and biological significance in health and disease.
