Analytical Data
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基因名
DLL4
- Application
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别名
DLL4;Delta-like Protein 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NR61
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表达区间
27-524aa
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氨基酸序列
SGVFQLQLQEFINERGVLASGRPCEPGCRTFFRVCLKHFQAVVSPGPCTF GTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAPG DDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICS DNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGC HEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGW GGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELS ECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGS CRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMC RCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCE VRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLP
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分子量
56 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DLL4 (Delta-like ligand 4) is a member of the Notch signaling pathway and plays a crucial role in regulating angiogenesis and lymphangiogenesis during development and in pathological conditions. It's primarily expressed in endothelial cells and is involved in the differentiation and function of various immune and stem cells. Research on DLL4 has gained momentum due to its implications in tumor biology, where it promotes the formation of a specialized vascular network that supports tumor growth and metastasis. The DLL4-Notch signaling axis has been shown to modulate tumor microenvironment interactions, influencing angiogenic sprouting and immune cell infiltration, thereby potentially serving as a therapeutic target for cancer treatment. Recombinant DLL4 protein is increasingly utilized in scientific studies to elucidate its biological functions and mechanisms of action. Specifically, researchers are investigating its potential role in enhancing or inhibiting tumor progression through targeted modulation of the Notch signaling pathway. Understanding the structure-function relationship of DLL4 through the use of recombinant forms can facilitate the development of DLL4-based therapeutics, such as monoclonal antibodies or small molecule inhibitors, aiming to control aberrant angiogenesis in various diseases, particularly cancer. Overall, DLL4 represents a significant focus of biological and pharmacological research aimed at unraveling its diverse functions in development, immunity, and pathology.
