Analytical Data
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Gene name
Slc17a8
- Application
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Alternative Names
(VGluT3)(Solute carrier family 17 member 8)
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Species
Rat
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Source
Yeast
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7TSF2
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Expression Region
1-76aa
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Molecular Weight
9.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Slc17a8, also known as vesicular glutamate transporter 2 (VGLUT2), plays a crucial role in the transport of glutamate into synaptic vesicles, thereby regulating synaptic transmission in the central nervous system. Research on the SLC17A8 protein has gained significant attention due to its implications in several neurological disorders, including schizophrenia, autism spectrum disorders, and various neurodegenerative diseases. Understanding the structure-function relationship of Slc17a8 is essential for elucidating its role in neurotransmission and synaptic plasticity. The recombinant expression of Slc17a8 enables researchers to produce large quantities of the protein, facilitating biophysical and biochemical characterizations. These studies can provide insights into the transport mechanisms of glutamate and the pharmacological potential of targeting this transporter for therapeutic interventions. Additionally, investigating the interactions of Slc17a8 with other proteins and cellular components can enhance our knowledge of its regulatory mechanisms in glutamatergic signaling. Thus, the research on recombinant Slc17a8 is vital for advancing our understanding of synaptic function and developing novel strategies for treating neurological conditions.
