Analytical Data
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基因名
ENG
- Application
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别名
ENG；END；Endoglin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P17813
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表达区间
1-658aa
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氨基酸序列
MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRSPSKREPVVAVAAPASSESSSTNHSIGSTQSTPCSTSSMA
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分子量
70.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ENG (Endoglin) is a key glycoprotein that plays a significant role in the regulation of angiogenesis, vascular development, and endothelial cell function. Research on ENG has gained considerable attention due to its implication in various pathological conditions, including preeclampsia, pulmonary arterial hypertension, and certain cancers. ENG is a coreceptor for transforming growth factor-beta (TGF-β) signaling, influencing cellular responses that are crucial for vascular homeostasis. Recent studies have highlighted the importance of ENG in modulating endothelial cell proliferation and migration, suggesting its potential as a therapeutic target in vascular diseases. Additionally, the exploration of ENG as a biomarker for diseases has prompted further investigation into its structural properties and functional mechanisms. The reconstitution of ENG in recombinant protein form has facilitated diverse experimental approaches, allowing researchers to decode its intricate interactions with other signaling pathways. This endeavor not only advances our understanding of vascular biology but also opens new avenues for the development of targeted therapies aimed at mitigating diseases associated with endothelial dysfunction. Overall, the study of ENG and its recombinant forms is pivotal in uncovering novel insights into angiogenesis and provides a promising foundation for innovative treatment strategies in vascular-related disorders.
