Analytical Data
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基因名
E5
- Application
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种属
Human papillomavirus type 16
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表达系统
E. coli
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标签
N- His & C- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P06927
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表达区间
1-83aa
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分子量
36.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
E5 protein, a small oncoprotein that is encoded by the human papillomavirus (HPV), has garnered significant attention in cancer research due to its role in viral pathogenesis and tumorigenesis. Discovered primarily in HPV types 16 and 18, E5 contributes to the oncogenic potential of the virus by modulating cellular signaling pathways, particularly by enhancing the activity of growth factor receptors and inhibiting apoptosis. This results in uncontrolled cellular proliferation and evasion of immune surveillance. Research indicates that E5 interacts with various cellular proteins, influencing processes such as cell cycle regulation, inflammation, and immune response. The significance of E5 in the context of HPV-related malignancies, particularly cervical cancer, underscores the need for a deeper understanding of its mechanisms and potential as a therapeutic target. Furthermore, the study of E5 may pave the way for the development of novel antiviral strategies and vaccine formulations, as well as contribute to the broader field of oncoprotein research. Overall, ongoing investigations into the biochemical properties and pathophysiological effects of E5 hold promise for advancing our knowledge of HPV biology and enhancing cancer treatment modalities.
