Analytical Data
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Gene name
Cacng1
- Application
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Alternative Names
(Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma)
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Species
Mouse
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O70578
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Expression Region
1-223aa
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Molecular Weight
26.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Cacng1, also known as the calcium channel voltage-dependent gamma 1 subunit, plays a crucial role in the modulation of calcium channels in excitable tissues, such as neurons and muscle cells. This subunit is essential in the formation and functioning of voltage-gated calcium channels (VGCCs), which are pivotal for various physiological processes, including neurotransmitter release, muscle contraction, and gene expression regulation. Abnormalities in Cacng1 expression or function have been implicated in several neurological disorders and cardiovascular diseases, underscoring its potential as a therapeutic target. Recent studies have focused on the recombinant production of Cacng1 to better understand its structure and function at a molecular level. By utilizing recombinant DNA technology, researchers can produce purified Cacng1 proteins for functional assays, binding studies, and structural analyses. These investigations aim to elucidate the mechanisms through which Cacng1 influences calcium channel activity and to explore how alterations in its function can lead to pathological states. Ultimately, enhanced knowledge of Cacng1's biology could pave the way for novel treatments for diseases associated with calcium signaling dysregulation.
