Cat: PA1000-1047

Recombinant Human EPOR Protein,His

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Analytical Data

  • 基因名

    EPOR

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    EPOR;Erythropoietin receptor

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P19235

  • 表达区间

    25-250aa

  • 氨基酸序列

    APPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGP GNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRV TAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPM TSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARM AEPSFGGFWSAWSEPVSLLTPSDLDPHHHHHH

  • 分子量

    26 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

The study of EPOR (Erythropoietin Receptor) and its recombinant proteins has gained significant attention due to its critical role in erythropoiesis, the process of producing red blood cells. Erythropoietin (EPO), a hormone primarily produced in the kidneys, binds to EPOR to stimulate red blood cell production, making it a crucial factor in treating various anemias, particularly in patients with chronic kidney disease or those undergoing chemotherapy. However, dysregulation of the EPOR signaling pathway can lead to disorders such as polycythemia or anemia. Recent advancements in recombinant DNA technology have enabled the production of modified EPOR proteins with enhanced therapeutic potential, aimed at improving efficacy, reducing side effects, and refining treatment protocols. Furthermore, understanding the structural and functional aspects of EPOR is vital for the development of new drugs and therapeutic strategies. Researchers are investigating the intricate signaling mechanisms, receptor dynamics, and the interaction of EPOR with other cellular pathways to uncover the nuances of its function. Additionally, exploring the potential of EPOR-related therapies in regenerative medicine and its implications in cancer biology are expanding the scope of research. This background sets the stage for ongoing studies focused on optimizing EPOR-based therapies, understanding its role in various physiological and pathological contexts, and addressing the challenges presented by its clinical applications.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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