Analytical Data
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Gene name
ETS2
- Application
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Alternative Names
ETS2;Protein C-ets-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P15036
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Expression Region
1-469aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MNDFGIKNMD QVAPVANSYR GTLKRQPAFD TFDGSLFAVF PSLNEEQTLQ EVPTGLDSIS HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP KNPWLWSEQQ VCQWLLWATN EFSLVNVNLQ RFGMNGQMLC NLGKERFLEL APDFVGDILW EHLEQMIKEN QEKTEDQYEE NSHLTSVPHW INSNTLGFGT EQAPYGMQTQ NYPKGGLLDS MCPASTPSVL SSEQEFQMFP KSRLSSVSVT YCSVSQDFPG SNLNLLTNNS GTPKDHDSPE NGADSFESSD SLLQSWNSQS SLLDVQRVPS FESFEDDCSQ SLCLNKPTMS FKDYIQERSD PVEQGKPVIP AAVLAGFTGS GPIQLWQFLL ELLSDKSCQS FISWTGDGWE FKLADPDEVA RRWGKRKNKP KMNYEKLSRG LRYYYDKNII HKTSGKRYVY RFVCDLQNLL GFTPEELHAI LGVQPDTED
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Molecular Weight
55 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of ETS2, an ETS (E26 transcription factor) family transcription factor, has garnered significant attention due to its pivotal role in regulating gene expression during development, differentiation, and cellular response to environmental stimuli. ETS2 is implicated in various biological processes, including oncogenesis, cellular proliferation, and apoptosis. Dysregulation of ETS2 has been associated with several cancers, making it a crucial target for understanding tumorigenesis and developing therapeutic strategies. Research has revealed that ETS2 functions not only as a transcriptional activator but also exhibits repressive characteristics under certain conditions, thereby contributing to a complex regulatory network. Moreover, the ability of ETS2 to interact with other transcription factors, co-factors, and chromatin remodeling complexes highlights its versatility and significance in gene regulation. The investigation of recombinant ETS2 proteins has advanced our understanding of its structural and functional properties, paving the way for potential applications in gene therapy and personalized medicine. Through molecular cloning and expression studies, researchers are exploring the mechanisms by which ETS2 influences gene networks, aiming to elucidate the pathways involved in its oncogenic functions. Understanding the multifaceted roles of ETS2 in normal and pathological states is critical for leveraging its potential in clinical applications, such as targeted cancer therapies and regenerative medicine.
