Analytical Data
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Gene name
CX26
- Application
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Alternative Names
CX26；Gap junction beta-2 Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P29033
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Expression Region
1-226aa
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AA Sequence
MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQAD FVCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRH EKKRKFIKGEIKSEFKDIEEIKTQKVRIEGSLWWTYTSSIFFRVIFEAAF MYVFYVMYDGFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSG ICILLNVTELCYLLIRYCSGKSKKPV
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Molecular Weight
51 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CX26, also known as Connexin 26, is a vital gap junction protein that plays a critical role in cell communication and homeostasis in various tissues, particularly in the cochlea of the inner ear, where it is essential for auditory function. Mutations in the CX26 gene (GJB2) are one of the most common genetic causes of non-syndromic hearing loss, affecting millions globally. Understanding the structure and function of CX26 protein is crucial for developing targeted therapies for hearing impairments associated with its mutations. Recent research has focused on characterizing CX26 recombinant proteins to investigate their biophysical properties, channel-forming capabilities, and interaction with other cellular proteins. Studies involving the overexpression of CX26 in various cell systems have revealed insights into its assembly, gating mechanisms, and the effects of specific mutations on its functionality. Additionally, CX26's role in cellular processes beyond the auditory system, including its involvement in skin physiology and certain diseases, has expanded its research relevance. Overall, the investigation of CX26 recombinant proteins offers promising avenues for therapeutic interventions, including gene therapy and regenerative medicine, aiming to restore hearing and improve quality of life for affected individuals.
