Analytical Data
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Gene name
KRT23
- Application
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Alternative Names
KRT23；Keratin. type I cytoskeletal 23
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9C075
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Expression Region
1-422aa
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AA Sequence
MNSGHSFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTR SCPPPGGSWGSGRSSPLLGGNGKATMQNLNDRLASYVEKVRALEEANMKL ESRILKWHQQRDPGSKKDYSQYEENITHLQEQIVDGKMTNAQIILLIDNA RMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQEVEGMR KELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYEL IIKKKHRDLDTWYKEQSAAMSQEAASPATVQSRQGDIHELKRTFQALEID LQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQ NNEYQVLLGIKTHLEKEITTYRRLLEGESEGTREESKSSMKVFATPKIKA ITQETINGRLVLCQVNEIQKHA
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Molecular Weight
48.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT23, or Keratin 23, is a type of intermediate filament protein that is primarily expressed in the epithelial tissues, particularly in the skin and the hair follicles. As a member of the keratin family, it plays a crucial role in maintaining the structural integrity and resilience of epithelial cells. Research on KRT23 has gained attention due to its potential implications in various dermatological conditions, including skin disorders and diseases associated with keratinization. Furthermore, alterations in KRT23 expression may be linked to the pathology of certain cancers, making it a subject of interest in cancer research. The study of KRT23 not only aids in understanding fundamental cellular processes but also provides insights into its possible role as a biomarker for disease progression and as a target for therapeutic interventions. Recent advancements in recombinant protein technology have enabled the production of KRT23, facilitating in-depth studies regarding its functional properties and interactions within cellular environments. Understanding KRT23's biochemical characteristics and its involvement in cellular pathways is essential for elucidating its role in health and disease, ultimately contributing to the development of novel diagnostic and therapeutic strategies involving keratin-based proteins.
