Analytical Data
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Gene name
FARS2
- Application
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Alternative Names
FARS2；FARS1;Phenylalanine--tRNA ligase. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95363
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Expression Region
37-451aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMPAAECATQRAPGSVVELLGKSYPQDDHSN LTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDN LSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLH AGLDAFLVVGDVYRRDQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESL QLFEQSSRSAHKQETHTMEAVKLVEFDLKQTLTRLMAHLFGDELEIRWVD CYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLG LERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKYPAVIN DISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYR ITYRHMERTLSQREVRHIHQALQEAAVQLLGVEGRF
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Molecular Weight
51 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FARS2 (PhenylalanyltRNA synthetase 2) is a mitochondrial enzyme that plays a crucial role in the protein synthesis process by attaching the amino acid phenylalanine to its corresponding tRNA. Deficiencies or mutations in FARS2 have been linked to various mitochondrial disorders and neurological conditions, highlighting its significance in cellular health and function. Recent studies have demonstrated that FARS2 is essential for mitochondrial protein synthesis and overall mitochondrial function, making it a potential target for therapeutic interventions. Researchers have focused on the recombinant production of FARS2 to explore its structural and functional properties, which could provide insights into its enzymatic mechanisms and interactions with other mitochondrial components. Furthermore, understanding the nuances of FARS2 function may lead to the development of novel strategies to address diseases associated with mitochondrial dysfunction. By using recombinant technology, scientists can generate large quantities of FARS2 for biochemical assays and structural biology studies, paving the way for advancements in targeted therapies for mitochondrial diseases.
