Analytical Data
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Gene name
IFNAR1
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简介
IFNAR1, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFNAR1 forms the heterodimeric receptor with IFNAR2. IFNAR1 mediates IFN-induced STAT signaling by interacting with tyrosine kinase 2 (Tyk2)[1][2]. Upon activation by these IFNs, IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2[3]. IFNAR1 Protein, Mouse (HEK293, Fc) is a recombinant mouse IFNAR1 (E27-T429) with C-terminal His and Avi tags, which is produced in HEK293 cells.
- Application
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Alternative Names
AVP; IFN-alpha/beta R1; IFN-alpha-REC; IFNAR; IFNAR1; IFN-aR1; IFNBR; IFNbR1; IFN-R-1; CRF2-1; IFRC ; IFN-alpha/β R1
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Species
Mouse
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Source
HEK293
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Tag
C-Avi;C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P33896
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Expression Region
E27-T429
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Protein Length
Extracellular Domain
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Molecular Weight
60-70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IFNAR1 (Interferon alpha/beta receptor subunit 1) is a crucial component of the type I interferon signaling pathway, which plays a pivotal role in the immune response to viral infections and other pathogens. The protein functions as a receptor for interferon-alpha and interferon-beta, mediating the activation of the JAK-STAT signaling cascade that results in the induction of numerous antiviral genes. Dysregulation of this pathway has been implicated in various diseases, including autoimmune disorders, cancer, and chronic viral infections. The recombinant production of IFNAR1 has garnered significant interest for a variety of applications, including the development of therapeutics that target the interferon signaling pathway, as well as for studying receptor biology and the broader immune signaling mechanisms. Understanding the structural and functional properties of IFNAR1 is vital for exploring its role in immune modulation and therapeutic interventions. Moreover, the recombinant protein can serve as a valuable tool for developing assays to screen for novel antiviral compounds and studying receptor-ligand interactions. Current research focuses on optimizing expression systems for high-yield production, characterizing the protein’s interactions with its ligands, and investigating its potential as a therapeutic target. The insights gained from IFNAR1 recombinant protein studies could lead to the advancement of innovative strategies to combat infectious diseases and enhance vaccine efficacy.
