Analytical Data
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基因名
GLb
- Application
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别名
GLb；Bgl；Glb-1；Beta-galactosidase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P16278
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表达区间
24-677aa
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氨基酸序列
NATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMA GLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPY ICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQ NGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHK TFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLD HWGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYA AQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYG KVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQD CSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDL LVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLG GWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPG WTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAP CSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLD HVVDHHHHHH
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分子量
74 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of GLB (glutamate dehydrogenase, also known as GLB protein) recombinant proteins has gained significant attention in recent years due to their pivotal role in cellular metabolic pathways, particularly in the regulation of glutamate levels within the nervous system and their potential implications in various neurological disorders. GLB proteins are crucial for the conversion of glutamate to α-ketoglutarate, playing a key role in amino acid metabolism and neurotransmission. Research has demonstrated that alterations in GLB protein function can contribute to pathological conditions such as epilepsy, Alzheimer's disease, and other neurodegenerative disorders. Recombinant GLB proteins provide a powerful tool for investigating the functional aspects of this enzyme, allowing for high-yield production and detailed characterization of its biochemical properties. Furthermore, understanding the structure-function relationship of GLB proteins through recombinant methods facilitates the development of targeted therapies and diagnostic tools aimed at mitigating the effects of glutamate dysregulation. This research not only aims to enhance our comprehension of glutamate homeostasis in the brain but also to explore innovative therapeutic avenues for treating related disorders. Overall, the study of GLB recombinant proteins represents a critical frontier in molecular neuroscience and offers insights into the intricate mechanisms underlying glutamate's role in health and disease.
