Analytical Data
-
基因名
CBX8
- Application
-
别名
CBX8；PC3；RC1；Chromobox Protein homolog 8
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9HC52
-
表达区间
1-389aa
-
氨基酸序列
MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSARGIRIPYPGRSPQDLASTSRAREGLRNMGLSPPASSTSTSSTCRAEAPRDRDRDRDRDRERDRERERERERERERERERERGTSRVDDKPSSPGDSSKKRGPKPRKELPDPSQRPLGEPSAGLGEYLKGRKLDDTPSGAGKFPAGHSVIQLARRQDSDLVQCGVTSPSSAEATGKLAVDTFPARVIKHRAAFLEAKGQGALDPNGTRVRHGSGPPSSGGGLYRDMGAQGGRPSLIARIPVARILGDPEEESWSPSLTNLEKVVVTDVTSNFLTVTIKESNTDQGFFKEKR
-
分子量
49.4 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CBX8 (Chromobox 8) is a member of the Polycomb group (PcG) proteins, which play a crucial role in the regulation of gene expression through chromatin remodeling and epigenetic modifications. Research on CBX8 has gained importance due to its involvement in various biological processes, including cellular differentiation, development, and the maintenance of stem cell pluripotency. Dysregulation of CBX8 has been linked to several diseases, particularly cancers, where it may function as an oncogene or tumor suppressor, depending on the context. Studies have shown that CBX8 can affect cellular pathways related to cell cycle regulation and apoptosis, making it a potential target for therapeutic strategies. The recombinant expression of CBX8 protein allows for the investigation of its functional roles and mechanisms of action in more detail. By producing CBX8 in a controlled laboratory environment, researchers can analyze its interactions with other proteins and nucleic acids, as well as its effects on gene expression. This research is integral to understanding the complexities of epigenetic regulation and offers insights into potential clinical applications in regenerative medicine and cancer therapy. Overall, the study of CBX8 recombinant protein holds promise for elucidating fundamental biological processes and developing novel therapeutic approaches.
