Analytical Data
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基因名
INSIG2
- Application
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别名
INSIG2；Insulin-induced gene 2 Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y5U4
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表达区间
1-225aa
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氨基酸序列
MAEGETESPG PKKCGPYISS VTSQSVNLMI RGVVLFFIGV FLALVLNLLQ IQRNVTLFPP DVIASIFSSA WWVPPCCGTA SAVIGLLYPC IDRHLGEPHK FKREWSSVMR CVAVFVGINH ASAKVDFDNN IQLSLTLAAL SIGLWWTFDR SRSGFGLGVG IAFLATVVTQ LLVYNGVYQY TSPDFLYVRS WLPCIFFAGG ITMGNIGRQL AMYECKVIAE KSHQE
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分子量
32 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
INSIG2 (Insulin Induced Gene 2) is a crucial protein involved in lipid metabolism and cholesterol homeostasis, functioning primarily in the regulation of sterol regulatory element-binding proteins (SREBPs). It serves as a key player in maintaining cellular lipid levels by facilitating the retention of SREBPs in the endoplasmic reticulum, thereby preventing their maturation and activation of lipogenic genes. The study of INSIG2, particularly through the production of recombinant INSIG2 protein, has garnered significant interest due to its potential implications in metabolic disorders, including obesity and type 2 diabetes. Recent research has suggested that genetic variations in the INSIG2 gene may also be associated with obesity susceptibility in humans, underscoring the importance of this protein in understanding metabolic pathways. The recombinant protein can be utilized in various biochemical assays to explore its molecular interactions and functional mechanisms, contributing to the development of therapeutic strategies aimed at targeting dysregulated lipid metabolism. Given its role in energy homeostasis, further investigation of INSIG2 and its interactions could provide insights into novel approaches for treating metabolic diseases and highlight its potential as a biomarker for obesity-related conditions.
