Analytical Data
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基因名
GSTa3
- Application
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别名
GSTa3；Glutathione S-transferase A3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16772
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表达区间
2-222aa
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氨基酸序列
AGKPKLHYF NGRGRMEPIR WLLAAAGVEF EEKFIGSAED LGKLRNDGSL MFQQVPMVEI DGMKLVQTRA ILNYIASKYN LYGKDIKERA LIDMYTEGMA DLNEMILLLP LCRPEEKDAK IALIKEKTKS RYFPAFEKVL QSHGQDYLVG NKLSRADISL VELLYYVEEL DSSLISNFPL LKALKTRISN LPTVKKFLQP GSPRKPPADA KALEEARKIF RF
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GSTa3 is a glutathione S-transferase (GST) from the alpha class, which plays a pivotal role in detoxifying harmful compounds and is involved in various cellular processes. The study of GSTa3 has garnered attention due to its significant implications in pharmacology, particularly in drug metabolism and resistance mechanisms in cancer cells. Research indicates that GSTa3 is overexpressed in various tumors, suggesting a potential role in tumor progression and chemoresistance. Understanding the structure and function of GSTa3 through recombinant protein studies can provide insights into its catalytic mechanisms and interactions with substrates. Additionally, GSTa3 serves as a useful model for designing targeted therapies that inhibit its activity, which could enhance the efficacy of conventional chemotherapeutic agents. The production of recombinant GSTa3 allows for detailed biochemical characterization, enabling researchers to elucidate its role in cellular detoxification pathways and explore its potential as a biomarker or therapeutic target in cancer treatment. As a result, ongoing research aims to reveal new strategies to counteract the adverse effects of GSTa3 overexpression in malignancies, making it a crucial focus in the quest for improved cancer therapeutics.
