Analytical Data
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Gene name
HNF4G
- Application
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Alternative Names
HNF4G; NR2A2Hepatocyte nuclear factor 4-gamma; HNF-4-gamma; Nuclear receptor subfamily 2 group A member 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14541
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Expression Region
1-408aa
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AA Sequence
MNTTDNGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI RKSHVYSCRF SRQCVVDKDK RNQCRYCRLR KCFRAGMKKE AVQNERDRIS TRRSTFDGSN IPSINTLAQA EVRSRQISVS SPGSSTDINV KKIASIGDVC ESMKQQLLVL VEWAKYIPAF CELPLDDQVA LLRAHAGEHL LLGATKRSMM YKDILLLGNN YVIHRNSCEV EISRVANRVL DELVRPFQEI QIDDNEYACL KAIVFFDPDA KGLSDPVKIK NMRFQVQIGL EDYINDRQYD SRGRFGELLL LLPTLQSITW QMIEQIQFVK LFGMVKIDNL LQEMLLGGAS NDGSHLHHPM HPHLSQDPLT GQTILLGPMS TLVHADQIST PETPLPSPPQ GSGQEQYKIA ANQASVISHQ HLSKQKQL
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Molecular Weight
45.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HNF4G (Hepatocyte Nuclear Factor 4 Gamma) is a transcription factor that plays a crucial role in the regulation of gene expression in liver and intestinal tissues. It is part of the nuclear receptor superfamily and is involved in various physiological processes, including lipid metabolism, glucose homeostasis, and the maintenance of intestinal epithelial integrity. Research into HNF4G has gained momentum due to its significant implications in metabolic disorders and its potential role as a therapeutic target for conditions such as diabetes, obesity, and liver diseases. The recombinant protein form of HNF4G is extensively studied to unravel its structure-function relationships and downstream gene targets, facilitating a deeper understanding of its biological mechanisms. This enables researchers to investigate its regulatory pathways and how alterations in HNF4G function may lead to disease. In addition to its fundamental biological significance, understanding HNF4G may also contribute to the development of novel strategies for disease prevention and treatment, highlighting the importance of recombinant protein studies in advancing our knowledge of metabolic health and disease. Overall, the investigation of HNF4G and its recombinant protein serves as a pivotal point for elucidating the complexities of metabolic regulation and opens avenues for innovative therapeutic interventions.
