Analytical Data
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Gene name
HOXC12
- Application
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Alternative Names
HOC3F; Homeo box 3F; Homeo box C12; Homeobox C12; Homeobox protein Hox-3F; Homeobox protein Hox-C12; Hox-3F ; HOX3; HOX3F; Hoxc12; HXC12_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P31275
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Expression Region
1-282aa
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AA Sequence
MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV CSLSWPSAEP CNGYPQPYLG SPVSLNPPFG RTCELARVED GKGYYREPCA EGGGGGLKRE ERGRDPGAGP GAALLPLEPS GPPALGFKYD YAAGGGGGDG GGGAGPPHDP PSCQSLESDS SSSLLNEGNK GAGAGDPGSL VSPLNPGGGL SASGAPWYPI NSRSRKKRKP YSKLQLAELE GEFLVNEFIT RQRRRELSDR LNLSDQQVKI WFQNRRMKKK RLLLREQALS FF
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Molecular Weight
30.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HOXC12 is a member of the homeobox gene family, which plays a critical role in the regulation of embryonic development and the patterning of various tissues. Research on HOXC12 has gained significance due to its involvement in developmental processes such as limb formation and organogenesis. Abnormal expression of HOXC12 has been linked to various diseases, including cancers, highlighting its potential as a biomarker or therapeutic target. Efforts to produce recombinant HOXC12 protein have been driven by the need to elucidate its functional mechanisms and interactions at the molecular level. By generating HOXC12 in a recombinant form, researchers aim to investigate its effects on gene regulation, protein interactions, and cellular pathways. This understanding could provide valuable insights into its role in both normal development and pathological conditions. Furthermore, recombinant HOXC12 can be utilized in various experimental assays, including structural studies, functional assays, and high-throughput screening to identify small molecules that might modulate its activity. The systematic study of HOXC12 and its recombinant forms is crucial for advancing our knowledge of homeobox genes and their implications in health and disease. Overall, the exploration of HOXC12 as a recombinant protein is poised to uncover important biological insights and facilitate the development of targeted therapies in regenerative medicine and oncology.
