Analytical Data
-
基因名
CK18
- Application
-
别名
CK18；Plakophilin-1
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P05783
-
表达区间
2-430aa
-
氨基酸序列
MASMTGGQQMGRGHHHHHHGNLYFQGEFSFTTRSTFSTNYRSLGSVQAPS YGARPVSSAASVYAGAGGSGSRISVSRSTSFRGGMGSGGLATGIAGGLAG MGGIQNEKETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQV RDWSHYFKIIEDLRAQIFANTVDNARIVLQIDNARLAADDFRVKYETELA MRQSVENDIHGLRKVIDDTNITRLQLETEIEALKEELLFMKKNHEEEVKG LQAQIASSGLTVEVDAPKSQDLAKIMADIRAQYDELARKNREELDKYWSQ QIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLENS LREVEARYALQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKL EAEIATYRRLLEDGEDFNLGDALDSSNSMQTIQKTTTRRIVDGKVVSETN DTKVLRH
-
分子量
51 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Recombinant Human HOXD13 Protein，GST
Cat：PA2000-8338
Recombinant E.coli EHT1 Protein，His
Cat：PA2000-4195
Recombinant Human ITGa2 Protein，His
Cat：PA2000-127DB
Protein Description
Cytokeratin 18 (CK18) is a type of intermediate filament protein predominantly expressed in epithelial cells, playing a crucial role in maintaining the structural integrity of tissues. The study of CK18 has gained prominence due to its association with various pathological conditions, including cancer, where its expression patterns may serve as potential biomarkers for diagnosis and prognosis. In particular, CK18 can be released into circulation upon cellular stress or apoptosis, making it a valuable indicator of tissue damage and disease progression. Research involving recombinant forms of CK18 has focused on exploring its functional properties, such as the role in cell signaling, apoptosis, and the overall cellular response to injury. By producing recombinant CK18, scientists aim to facilitate detailed investigations into its biochemical behavior, interactions with other proteins, and its potential role in therapeutic applications, including targeted cancer therapies and regenerative medicine. Understanding the molecular mechanisms underlying CK18's functions could lead to innovative diagnostic tools and treatment strategies, thereby enhancing our ability to manage diseases associated with epithelial tissues.
