Analytical Data
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Gene name
IFN-lambda 2/IL-28A
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简介
IFN-lambda 2/IL-28A protein is a cytokine with antiviral, antitumor, and immunomodulatory activities. It plays a key role in the antiviral defense of epithelial tissues by binding to IL10RB and IFNLR1 receptor complexes, activating the JAK/STAT signaling pathway. IFN-lambda 2/IL-28A Protein, Mouse (HEK293, N-His) is the recombinant mouse-derived IFN-lambda 2/IL-28A protein, expressed by HEK293 , with N-6*His labeled tag.
- Application
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Biological Activity
Measured in a cell inhibitor assay using A549 cells. The ED50 for this effect is 2.972 ng/mL, corresponding to a specific activity is 3.365×105 units/mg. Measured in a cell inhibitor assay using A549 cells. The ED50 for this effect is 2.972 ng/mL , corresponding to a specific activity is 3.365×105 units/mg.
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Alternative Names
Interferon-λ2, IFN-λ2, IL-28A
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Species
Mouse
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Source
HEK293
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Tag
N-6*His
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Uniprot
Q4VK74
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Expression Region
D20-193V
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Protein Length
Full Length of Mature Protein
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Molecular Weight
27 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Ephrin-A1 (EFNA1) is a member of the ephrin family of proteins, which play crucial roles in developmental processes and cell communication through Eph receptor interactions. Originally identified in the context of neural development, Ephrin-A1 is involved in various physiological and pathological processes, including cell adhesion, migration, and angiogenesis. Research surrounding Ephrin-A1 has gained momentum due to its potential implications in cancer biology, particularly in tumor progression and metastasis. Studies have demonstrated that Ephrin-A1 can influence the behavior of tumor cells, potentially altering their invasiveness and ability to form secondary tumors. Furthermore, its role in the immune response highlights its significance in inflammatory diseases and tissue repair mechanisms. As a result, the production of recombinant Ephrin-A1 protein has become a focal point for researchers aiming to elucidate its functional roles and therapeutic potential. By studying the properties and interactions of this protein, scientists hope to develop novel strategies for targeting Ephrin-A1 in various diseases, offering new avenues for intervention in cancer therapy and regenerative medicine. Understanding the molecular mechanisms by which Ephrin-A1 operates may provide insights into its dualistic role in both promoting and inhibiting tumor growth, making it a promising target for future research and clinical applications.
