Analytical Data
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基因名
Ush1c
- Application
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别名
USH1C;AIE75;Harmonin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y6N9
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表达区间
1-533aa
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氨基酸序列
MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF
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分子量
76.3kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Ush1c (USH1C gene product) is a key protein implicated in Usher syndrome type IC, a genetic disorder leading to hearing loss and vision impairment. Research into Ush1c is critical because it plays a vital role in the development and maintenance of sensory hair cells in the inner ear and photoreceptor cells in the retina. Mutations in the Ush1c gene have been linked to progressive sensorineural hearing loss and retinitis pigmentosa, making the understanding of Ush1c essential for developing potential therapeutic strategies. The study of Ush1c as a recombinant protein allows researchers to investigate its structure, function, and interactions at a molecular level, contributing to the elucidation of its role in cellular processes. By producing Ush1c in a controlled environment, scientists can perform various assays to assess how specific mutations affect protein function and cellular pathways, ultimately aiming to identify targets for gene therapy or pharmacological intervention. The ongoing research efforts focus on understanding the underlying mechanisms of Ush1c in sensory cell function and exploring its potential as a biomarker for Usher syndrome, offering hope for the development of effective treatments for individuals affected by this debilitating condition.
